Mrinal K. Dewanjee, MSc, PhD, FAHA, FAIMBE
Consultant, Stem Cell Therapy, CBER, FDA.
Phone: 301-827-0693 (W), 240-686-4599 (H),
Education and Biography
Mrinal K. Dewanjee majored in Chemistry with Distinction in Physics and Mathematics from Dakha University (BSc, 1960). He received MSc in Inorganic Chemistry from Dakha University (1962, Bangladesh) and PhD in Nuclear Science from McGill University (Mechanism of nuclear spallation reactions with proton beams, 1967). He did post-doctoral research in chemical reactions using molecular beams and mass spectrometry in Amherst College (1967-1968) and Rensselaer Polytechnic Institute in nuclear spectroscopy (1968-1971). He made his impact by designing the first nuclear probes of Tc-99m Tetracyclines for imaging heart muscle damage in animal models and patients at Peter Bent Brigham Hospital, now BWH (Harvard Medical School, 1971-1973) and initiated the field of Cardiovascular Nuclear Medicine.
After working as the Director of Radioactive Drug Laboratory in Diagnostic Nuclear Medicine and Associate professor of Radiology at Tufts-New England Medical Center (1973-1976), he was hired as a Staff Consultant and Professor of Pathology and Radiology at Mayo Clinic (1976-1987). In collaboration with cardiologists, thoracic and vascular surgeons, interventional radiologists, hematologists, pathologists, pharmacologists, mechanical and bio-engineers, he developed the method of dynamic imaging platelet thrombi in coronary heart disease using radioactive platelets. His algebraic equations gave the foundations of measurement of adherent thrombi (Platelet density/area) using In-111 tropolone tagged platelets in coronary bypass grafts, angioplasty, stroke, synthetic vascular grafts, heart valves, catheters, heart-lung machines in a large number of animal models and patients. This metrology of arterial thrombi and emboli also helped us to evaluate the drug-dose and route of delivery of most of the small molecules (aspirin, Persantine, Ticlopidine/Plavix, Prostacycline, Ibuprofen, Naproxen) and recombinant hirudin. He joined the University of Miami-Jackson Medical Center as a Professor of Radiology, Surgery and Bioengineering and continued the investigations on the complications of open heart surgery on damage to brain, heart and kidneys in collaboration with device manufacturers, Baxter, Medtronic, Bjork-Shiley, Cordis and Beckman-Coulter and development of DNA and antibody probes for the diagnosis of cancer (1987-1996). His research projects was funded by NHLBI, Device and Drug Industry and Universities for more than 30 years. He served as a Professor of Bioengineering, Physiology and Nuclear Medicine at University of Illinois at Urbana-Champaign for four years (1996-2000) and enjoyed teaching the residents, fellows and graduate and technology students in nuclear medicine, radiology, cardiology and bioengineering at academic centers.
He joined Advanced Technology Program at National Institute of Standards and Technology (NIST, Dept. of Commerce) as a Biotechnology Manager on funding and managing commercial projects in genetic engineering of proteins/ transplantable organs and tissue engineering (2000-2004). In 2004, he joined NIH Radiology Research Laboratory and developed the universal cell-tagging Gd-probe for MRI. In 2005, he joined the Center for Biologics Evaluation and Research (FDA) and has been evaluating the stem cell-tagging methods for imaging the location and survival of transplanted neural stem cells in mouse brain using MRI and nuclear probes for promoting the practice of cell therapy in regenerative medicine.
Representative Publications (20/200)
1. Dewanjee MK, Saha GB, Yaffe L: Average recoil products from nuclear reactions induced in 65Cu and 197Au by protons of energy 20-85 MeV. CANADIAN J CHEMISTRY 46:3551-3563, 1968.
2. O'Kon OB, Bakhru H, Dewanjee MK, and Preiss IL: Decay of 49Cr isotope. PHYSICS REVIEW 7:239-242, 1973.
3. Holman BL, Dewanjee MK, Iodine J. Fliegel C. Davis MA, Treves S, and Eldh Per: Detection and localization of experimental myocardial infarction with Tc-99m tetracycline. JOURNAL OF NUCLEAR MEDICINE 14:595-599, 1973.
4. Dewanjee MK and Prince EW: Cellular necrosis model in tissue culture: Uptake of Tc-99m-tetracyclines and pertechnetate ion. JOURNAL OF NUCLEAR MEDICINE 15:577-581, 1974.
5. Dewanjee MK, Rao SA, Didisheim P: Indium-111 tropolone, a new high-affinity platelet label: Preparation and evaluation of labeling parameters. JOURNAL OF NUCLEAR MEDICINE 22(11): 981-987, 1981.
6. Robertson JS, Dewanjee MK, Brown ML, Fuster V, and Chesbro JH: Distribution and dosimetry of In-111-labeled platelets. RADIOLOGY 140:169-176, 1981.
7. Dewanjee MK, Pumphrey CW, Murphy KP, Fuster VD, Kaye MP, Rosemark JA, Chesebro JH: Evaluation of platelet-inhibitor drugs in a canine bilateral femoral graft implant. TRANSACTIONS OF AMERICAN SOCIETY OF ARTIFICIAL INTERNAL ORGANS 28:504-509, 1982.
8. Dewanjee MK, Fuster V, Rao SA, Forshaw PL, Kaye MP: Noninvasive radioisotopic technique for detection of platelet deposition on mitral valve prostheses and quantification of visceral microembolism in dogs. MAYO CLINIC PROCEEDINGS 58:307-314, 1983.
9. Dewanjee MK, Tago M, Josa M, Fuster V, Kaye MP: Quantification of platelet retention in aortocoronary femoral vein bypass graft in dogs treated with dipyridamole and aspirin. CIRCULATION 69:350-356, 1984.
10. Didisheim P, Tirrell MV, Lyons CS, Stropp JQ, Dewanjee MK: Relative role of surface chemistry and surface texture in blood material interactions. TRANS AMERICAN SOCIETY OF ARTIFICIAL INTERNAL ORGANS 29:169-176, 1983.
11. Steele PM, Chesebro JH, Stanson AW, Holmes DR, Jr., Dewanjee MK, Badimon L, Fuster V: Balloon angioplasty. Natural history of the pathophysiological response to injury in a pig model. CIRCULATION RESEARCH 57(1):105-112, 1985.
12. Dewanjee MK, Solis E, Mackey ST, Lenker J, Edwards WD, Didisheim P, Chesebro JH, Zollman PE, Kaye MP: Quantification of regional platelet and calcium deposition on pericardial tissue valve prostheses in calves and effect of hydroxyethylene diphosphonate. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 92:337-348, 1986.
13. Forstrom LA, Dewanjee MK, Chowdhury S, Brown ML: Indium-111 labeled purified granulocytes in the diagnosis of synthetic vascular graft infection. CLINICAL NUCLEAR MEDICINE 13: 859-862, 1989.
14. Dewanjee MK, Rowland S, Kapadvanjwala M, Georgiou M, Palatianos G, MacGregor D, Sfakianakis GN: The dynamics of platelet-thrombus formation rate (TFR), thrombus retention time (TRT) and rate of embolization (ROE) on control (CPC) and heparin bonded polyurethane angiocatheter (HBPC) with In-111 labeled platelets (IN-PLT) in a dog model. TRANS ASAIO 36: M745-M749, 1990.
15. Dietrich WD, Dewanjee S, Prado R, Watson BD, Dewanjee MK: Transient platelet accumulation in the rat brain after common carotid artery thrombosis: An 111In-labeled platelet study. STROKE 24: 1534-1540, 1993.
16. Schoephoerster RT, Oynes F, Nunez G, Park DC, Ramirez JA, Dewanjee MK: Effect of local geometry and fluid dynamics on regional platelet deposition on artificial surfaces. ATHEROSCLEROSIS AND THROMBOSIS 13: 1806-1813, 1993.
17. Dewanjee MK, Ghafouripour AK, Kapadvanjwala M, Dewanjee, S, Serafini AN, Lopez DM, Sfakianakis GN: Noninvasive imaging of c-myc oncogene mRNA with in-111 labeled antisense probes in mammary tumor-bearing mouse. JOURNAL NUCLEAR MEDICINE 35: 1054-1063, 1994.
18. Dewanjee MK, Wu SM, Kapadvanjwala M, De D, Dewanjee S, Novak S, Hsu LC, Perryman RA, Serafini AN, Sfakianakis GN, Duncan RC, Dietrich WD, Horton AF. Effect of thoracotomy and cardiopulmonary bypass on activated platelet and neutrophil dynamics and platelet-emboli in a pig model. J Throm Thrombolysis 3: 195-208, 1996.
19. Dewanjee MK, Zhai P, Hsu LC, Twardock AR. A new method for quantitation of platelet microthrombi and microemboli in devices and organs with indium-111 labeled platelets from cardiopulmonary bypass. ASAIO J 43: M701-M705, 1997.
20. Bluestein D, Niu L, Schoephoerster RT, Dewanjee MK. Fluid mechanics of arterial stenosis: Relationship to the development of mural thrombus. Annals of Biomedical Engineering 25: 344-356, 1997.